Journal of Agriculture & Life Sciences

Human Gut Microbiome Metabolism and Autism Spectrum Disorder
Martin Noguera

Abstract
Human gut microbiome and microbial metabolism correlations with gastrointestinal and extra intestinal disease and/or disorder have been explored heavily in recent years. Interest in correlations with mental health disease and disorder is of interest due to growing mental health issues in the United States and around the world as well. Clinically diagnosed individuals with Autism spectrum disorder exhibit gastrointestinal symptoms such as constipation, dysbiosis, abdominal pain, diarrhea, and increased intestinal permeability. The enteric nervous system can communicate with the central nervous system through neurochemical signals that are stimulated by microbial associated molecular patterns and metabolite production. This so-called gut-brain axis can, therefore, be exploited for novel therapeutics that inhibit atypical neurochemical signaling produced by altered microbial composition and microbial metabolic means.

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